Our data showed that over-expression of CRLF1 inhibited BMSCs viability, induced apoptosis, and suppressed chondrogenic differentiation of BMSCs. In addition, CRLF1 is reportedly expressed in osteoblasts and chondrocytes, and its expression was elevated in SW1353 chondrosarcoma cells transduced by the key chondrogenic transcription factor SOX9 (Dagoneau et al. 2007). This evidence concerns the gene SOX9 and chondrosarcoma.