It is interesting to note that although Forkhead transcription factor genes FOXK2, FOXN2, FOXJ3, and FOXO3 are highly expressed in both Fujioka AML cells and FOXC1high primary AMLs (Figures S2B and S2C), their gene products all lack the conserved Wing 2 amino acid sequence found in FOXC1 required for the RUNX1 and CEBPA interaction (Figure S2G). Here, RUNX1 is linked to acute myeloid leukemia.