These are derived from a child with acute monocytic leukemia and exhibit a t(10;11) translocation indicative of a CALM-AF10 fusion, as well as mutations in NRAS, ETV6, TP53, and EZH2, among others (Table S1; Hirose et al., 1982; Narita et al., 1999). The gene discussed is EZH2; the disease is acute monocytic leukemia.