High FOXC1 expression in AML is almost invariably found in association with high HOXA/B gene expression, and ∼30% of human HOXA/B-expressing AML cases (e.g., those with NPM1 mutations, MLL-fusions, or a t(6;9) translocation) exhibit high FOXC1 expression. Here, NPM1 is linked to acute myeloid leukemia.