Thus, FOXC1 interacts with CEBPA and with the Runt domain of RUNX1 through residues in its Forkhead domain, including the Wing 2 region, raising a question as to whether the functional effects of FOXC1 misexpression in AML are mediated through its interaction with one or both of these proteins. This evidence concerns the gene CEBPA and acute myeloid leukemia.