Thus, FOXC1 interacts with CEBPA and with the Runt domain of RUNX1 through residues in its Forkhead domain, including the Wing 2 region, raising a question as to whether the functional effects of FOXC1 misexpression in AML are mediated through its interaction with one or both of these proteins. The gene discussed is FOXC1; the disease is acute myeloid leukemia.