Xu et al.48reported that celecoxib, another COX‐2 inhibitor, inhibits the proliferation of cyst‐lining epithelial cells of patients with ADPKD and delays the progression of cyst formation in Pkd1‐knockout mice by downregulating the VEGF/Raf/MAPK/ERK signalling pathway. This evidence concerns the gene PKD1 and cyst.