NOTCH3 and Alzheimer disease: Among them, five rare variants showed nominal associations with AD risk, namely NOTCH3 rs201436750 (p = 1.80 × 10−2), COL4A1 rs747972545 (p = 2.03 × 10−2), COL4A1 rs201481886 (p = 2.41 × 10−2), CST3 rs765692764 (p = 2.87 × 10−2), and CST3 rs140837441 (p = 4.36 × 10−2) (Table 4).