ITM2B and Alzheimer disease: In the AAO association study, although no variants reached statistical significance after the Bonferroni correction, five variants were nominally associated with AD, including GSN rs9102 (p = 1.47 × 10−2), ITM2B rs11556899 (p = 2.65 × 10−2), COL4A1 rs9588116 (p = 4.01 × 10−2), COL4A1 rs645114 (p = 4.20 × 10−2), and COL4A1 rs9521650 (p = 4.53 × 10−2).