Decreased Csfr1 expression in Zeb2- and potentially Zeb1 null HSPCs could contribute to the loss of monocyte development observed in Zeb1 and Zeb2 individual KO and DKO settings as well as the enhanced monocyte skewing observed in Rosa26 locus based Zeb1/2 transgenic cDNA-based overexpression models as well as potential roles in AML progression [58]. This evidence concerns the gene ZEB2 and acute myeloid leukemia.