ZEB2 and acute lymphoblastic leukemia: Alternatively, overproduction of ZEB2 specifically in the murine hematopoietic system or in T cells can also selectively lead to T-cell transformation, with mice developing an early block in T-cell development that resembles human early thymic progenitor acute lymphocytic leukemia (ETP-ALL), whereby patients also display up-regulated ZEB2 [15].