Based on covariate adjusted LCA of cumulative infection-exposure data collected throughout the first 5 years of life, LC 1 membership was associated with lower probabilities of SPT positivity for Dermatophagoides and for any of the other allergens (any of Dermatophagoides mix, B. tropicalis, German cockroach, cat, mould, grass pollen, Bermuda grass or peanut); there was some suggestion of difference between the two LCs for eczema but for SPT positivity for Blomia, or cockroach, wheeze, rhinitis, and the IgE outcomes there was no suggestion of a difference (Table 4). The gene discussed is AGXT; the disease is rhinitis.