IGHE and infection: Based on covariate adjusted LCA of infection data collected during the first year of life, LC 1 membership was associated with lower probabilities of wheeze, eczema, rhinitis, and SPT positivity for Dermatophagoides; there was some suggestion of difference between the two LCs for SPT positivity overall and for Blomia (with SPT positivity less common for LC 1 children) but for cockroach and the IgE outcomes there was no suggestion of a difference (Table 3).