The NO-sGC-cGMP signal transduction pathway is impaired in different cardiovascular diseases, including pulmonary hypertension, heart failure, and chronic kidney diseases (CKDs) (Stasch et al., 2011) Gheorghiade et al., 2013) (Krishnan et al., 2018) (Hofmann, 2020). Here, SGCB is linked to pulmonary arterial hypertension.