MELK is overexpressed in multiple human cancers, such as colorectal cancer (Ding et al. 2020), melanoma (Janostiak et al. 2017), and basal-like breast cancer cells (Wang et al. 2014) and is a cell cycle-regulated gene regulated by E2F transcription factors (Verlinden et al. 2005). The gene discussed is MELK; the disease is breast cancer.