Efferocytosis-targeting strategies such as blockage of CD47 ‘don’t eat me’ signalling dramatically reduced atherosclerosis in ApoE−/− through the improvement of debris clearance by macrophages.78 CD47 inhibition is already considered for cancer therapy, making clinical translation to atherosclerosis potentially easier79 and recently CD47-interference nanotherapy was shown to have a favourable outcome in atherosclerotic ApoE−/− mice.80 The gene discussed is CD47; the disease is atherosclerosis.