GBP5 and tuberculosis: In 2016, Sweeney et al identified a combinatory score (TB score) based on blood messenger RNA (mRNA) expression levels of 3 differentially expressed genes (guanylate binding protein 5 [GBP5], dual specificity phosphatase 3 [DUSP3], and Krüppel-like factor 2 [KLF2]), for discrimination between active TB and other diseases [4] and was found to approach the TPP for a non-sputum-based triage test across 3 independent prospective cohorts [5].