This marker is also present in the pericytes, which are perivascular cells that surround the endothelium of capillaries and microvessels.13,35 CD146 expression was related to the epithelial-mesenchymal transition in cancer;36,37 however, to the best our knowledge, this marker has not been reported in epithelial-mesenchymal interaction in tooth development. Here, MCAM is linked to cancer.