In Kaplan–Meier Plotter dataset, we found that higher level of HMGCS1 was linked to shorter OS in multiple tumor types, including BCA (bladder carcinoma), CSCA, HNSC, PDAC, SARC, UCEC, BRCA, CESC, CHOL, KICH, LUAD, MESO, and THCA (Figure 2A, C). Here, HMGCS1 is linked to neoplasm.