Moreover, the stimulation of PPARγ in cancer cells using pioglitazone could induce apoptosis and cell cycle arrest through suppressing the activation of signal transducers and activator of transcription 3 (STAT3) and BIRC5 (SURVIVIN; OMIM number *603352) expression, and enhancing the apoptosis‐inducing factor (AIF) levels in the cells (Tsubaki et al., 2018). This evidence concerns the gene PPARG and cancer.