Of great interest, when we stimulated PPARγ in U937 cells, we found not only the transition of the leukemic cells from the G1 phase of the cell cycle was blocked, but also there was a significant increase in the number of the cells that underwent apoptotic death; suggestive of the efficacy of pioglitazone in the treatment of mutant PTEN‐expressing AML‐derived U937 cells. This evidence concerns the gene PPARG and acute myeloid leukemia.