The results of the molecular investigations declared that in addition to the suppressive effect of the agent on metabolic activities, the significance of pioglitazone in cancer treatment is due to its ability to interact with nuclear receptor peroxisome proliferator‐activated receptor‐γ (PPARγ; Ninomiya et al., 2014; Saiki et al., 2006), which is one of the most important receptors for transmitting the anti‐survival signals in the malignant cells (Shen et al., 2012). Here, PPARG is linked to cancer.