Whereas patients with CM with mild thrombocytopenia were characterized by moderately high PfHRP2 levels and elevated levels of multiple Group A–EPCR var transcripts (CIDRα1.5, CIDRα1.6, and DBLα1.7-DC13) (AUC, 0.82 [95% CI, 0.74–0.91]) (Figure 7A, left panel; Figure 7B), only extremely high PfHRP2 levels discriminated patients with CM with severe thrombocytopenia from patients with UM (AUC, 0.92 [95% CI, 0.86–0.98]) (Figure 7A, middle panel; Figure 7B). The gene discussed is CMC2; the disease is cutaneous mastocytosis.