Indeed, it has been shown that SLFN11 is strictly correlated with immune-related transcripts in breast cancer (13), and its expression is regulated by IFN signaling in primary human cells (14, 16) as well as possibly in neoplastic cells (6, 12), hence pointing toward an exogenous regulation of its levels by the tumor-infiltrating immune milieu. Here, SLFN11 is linked to breast cancer.