CCR5 and cancer: These transcripts include IFN regulatory factor 1 (IRF1), a master regulator of inflammation necessary for the development of immune-mediated cancer rejection (36, 43), and CCL5 and CXCL10, which, by binding to CCR5 and CXCR3, respectively, are the main mediators of intratumor chemoattraction of activated CXCR3+CCR5+ cytotoxic T cells (44, 45).