Moreover, in humans, a member of the DYRK1 subgroup, DYRK1A, induced the destabilization of microtubules via the hyperphosphorylation of tau proteins, which is a causal agent of Alzheimer’s disease (Ryoo et al. 2007; Woods et al. 2001). Here, DYRK1A is linked to early-onset autosomal dominant Alzheimer disease.