In 2015, three knockout monkey models based on CRISPR/Cas9 were published, including the P53 knockout cynomolgus monkey model [20], Duchenne muscular dystrophy (DMD) rhesus monkey model [38], and X-linked adrenal hypoplasia congenita-hypogonadotropic hypogonadism (AHC-HH) cynomolgus monkey model [39]. The gene discussed is TP53; the disease is Duchenne muscular dystrophy.