In mouse models on a HFD, NDL PCBs, e.g. Aroclor 1260, increased diet-induced hepatic steatosis, inflammation and fibrosis by affecting pathways regulated by epidermal growth factor receptor (46–49), constitutive androstane receptor (CAR, Nr1i3) and Pregnane X receptor (PXR, Nr1i2) [3, 16, 17]. Here, NR1I2 is linked to fatty liver disease.