Class I myosins recently have gained interest in cancer research because some are over expressed and contribute to increase disease severity, for example Myo1b in head and neck squamous cell carcinoma (HNSCC) promotes cell migration and lymph node metastasis, Myo1e in breast cancer promotes proliferation and tumor de differentiation [24, 30], some others are down regulated like Myo1a in colon cancer were seems to function as a tumor suppressor [25, 26]. The gene discussed is MYO1E; the disease is head and neck squamous cell carcinoma.