And recently class I myosins have been gained interest in the cancer field because some of them function as tumor suppressors and some others are over expressed in different cancers [20–22], however so far there is no indication of the direct involvement of Myo1g in cancer, therefore the aim of this study was to determine the expression levels of Myosin 1g in blood cells of patients with acute lymphoblastic leukemia and to correlate this expression with the severity of the disease and with treatment outcomes in children with ALL. Here, MYO1G is linked to cancer.