The analysis of Myo1g expression in Leukemia showed that is a molecule that participates in the development of the pediatric ALL and together with the clinical characteristics could strengthen the initial diagnosis, although we know that the diagnosis of ALL is confirmed by the bone marrow aspirate, an extra indication in PBMCs could contribute to the correct patient stratification, further studies are necessary to define and to identify the underlying biochemical and functional mechanisms of the over expression of this myosin in the leukemic cells. The gene discussed is MYO1G; the disease is leukemia.