ALDH1A1 and neoplasm: In ALDH1-A1 analysis we could note that 4bt was able to down regulate its expression in an expressive and significant way both when used as monotherapy and when used as adjuvant therapy with drug combination (Figure 6A) leading the median of the percentage of high positive and positive area from 34.31, in vehicle group, to 10.16 (4bt) and 4.26 (AC-4bt), and wide part of tumor was scored as low-positive.