In the present study, our goals were to examine the gene expression and UDP-sugar profile changes in human prostate cancer patient-derived xenograft (PDX) pairs representing castration sensitive (CS) and CR tumors, each pair originally from the same patient, and to determine whether UGDH served as a control point for directed channeling of UDP-GlcA through its downstream fates as reflected in tumors. The gene discussed is UGDH; the disease is Familial prostate cancer.