LIN28B and pancreatic adenocarcinoma: This model is similar to what was recently described in a study of pancreatic adenocarcinoma (PDAC), in which an unbiased screen identified LIN28B as a signature of small subpopulation circulating tumour cells with high metastasis propensity and most correlate with poor clinical outcome even when LIN28B is expressed in only a small subpopulation of primary PDAC tumours [29].