CD274 and non-small cell lung carcinoma: To address the role of MRTF-A in mediating the upregulation of PD-L1 expression that contributes to immune escape and NSCLC tumorigenesis in vivo, we established Lewis cell lines with stable MRTF-A knockdown (sh-MRTF-A) and negative control cells (NC) using the CRISPR-Cas9 genome-editing system to study the biological functions of MRTF-A in a murine model.