The cancer cell-killing ability of NK-92 cells after TGF-β treatment was significantly attenuated at all E:T ratios compared with that of control cells (Fig. 3j and Supplementary Fig. 2e–g), and MRTF-A siRNAs clearly counteracted the TGF-β-induced reduction in the killing ability of NK-92 cells. This evidence concerns the gene MRTFA and cancer.