Inflammation reaction plays an important role in the formation of aortic dissection, because inflammation could destroy the medial layer of the aortic wall, eventually leading to dilation, dissection, or rupture of the aortic wall and after the acute onset of AAD, mechanical injury in the lesion of aorta wall can stimulate the expression of neutrophil chemotactic factor and granulocyte colony stimulating factor, thus promoting neutrophils migration, and accumulation of a large number of neutrophils in the dissection vessel wall. Here, CSF3 is linked to Aortic dissection.