Further, concentrations of CEs, CHF, CHT, and PLs increased by 8.8, 1.5, 2.8-fold on average in VLDL, LDL, and IDL respectively, but no significant changes were detected in the HDL subunit between winter hibernating and summer active bears (Fig. 3A, Supplementary Table S2). This evidence concerns the gene SLC5A7 and congestive heart failure.