CD4 and Arthritis: We also evaluated the onset and severity of arthritis induced by the adoptive transfer of CD4+ T cells from WT or Gsdmd−/−SKG mice into Rag2−/− or Gsdmd−/−Rag2−/− mice, which enables us to dissect the specific role of Gsdmd in CD4+ T cells and non-CD4+ T cells in recipient mice, separately (Fig. 2E).