CD4 and arthritic joint disease: In addition, adoptive transfer experiments using CD4+ T cells from WT or Ripk3−/−SKG mice also revealed no significant differences in the clinical arthritis scores or the proportions of arthritogenic Th17 cells in draining LNs and inflamed joints from the recipient Rag2−/− or Ripk3−/−Rag2−/− mice, albeit a marginal decrease in the proportions of IFN-γ- and GM-CSF-producing Th cells in the inflamed joints (Fig. 4E–H).