Recent reports using Gsdmd−/− or Ripk3−/− mice revealed a pivotal role of pyroptosis and necroptosis in several tissue injuries and disease models, such as non-alcoholic hepatitis, familial Mediterranean fever (FMF), experimental autoimmune encephalomyelitis (EAE), cerulean-induced pancreatitis, ischemia/reperfusion injury, and kidney transplantation9–14. Here, RIPK3 is linked to familial Mediterranean fever.