TNF and cancer: There were additionally several highly enriched KEGG pathways, including platelet activation, hematopoietic cell lineage, cell adhesion molecules (CAMs), focal adhesion, leukocyte transendothelial migration, phagosome, Rap1 signaling pathway, regulation of actin cytoskeleton, osteoclast differentiation, cell cycle, natural killer cell mediated cytotoxicity, malaria, axon guidance, proteoglycans in cancer, progesterone-mediated oocyte maturation, estrogen signaling pathway, chemokine signaling pathway, NF-kappa B signaling pathway, MAPK signaling pathway, and TNF signaling pathway (Fig. 4c,d).