For example, 14-3-3β and 14-3-3γ were found to be at the center of some transcriptionally deregulated pathways in PD patients13, while isoforms -γ and -η show the strongest affinities for leucine-rich repeats kinase 2 (LRRK2), a key protein in the onset of familial and sporadic PD (see below)14. The gene discussed is LRRK2; the disease is Parkinson disease.