Importantly, 14-3-3s are present in LBs and are known to interact and co-localize with several proteins involved in PD pathogenesis, including LRRK2, α-Syn, and parkin (Fig. 3b, top left box)124 or in other neurodegenerative disorders with parkinsonian syndrome such as hereditary spastic paraplegia caused by mutations in SPG11125. This evidence concerns the gene PRKN and Parkinson disease.