The ratios of PTBP2 exon 10 skipping/inclusion, INSR exon 11 skipping/inclusion (the ratio of INSR-A/INSR-B) and ECT2 exon 4 skipping/inclusion are indeed significantly increased in malignant glioma, especially in GBM patient samples when compared to normal brain (Fig. 6g). Here, ECT2 is linked to glioblastoma.