Taken together, these findings demonstrate that SON overexpression in malignant gliomas, especially in GBM, has strong correlations with PTBP1 overexpression and PTBP2 downregulation, suggesting that there is a functional connectivity between SON, PTBP1, and PTBP2 in glioblastoma cells. Here, PTBP1 is linked to malignant glioma.