To determine the effect of multifunctional liposomes on impaired learning and memory in AD mice, 6-month-old APP/PS1 mice and age-matched wild-type (WT) littermates were intravenously injected with Tf-Pep63-Lip, Tf-Lip or saline as a vehicle every other day for 30 days. This evidence concerns the gene TF and Alzheimer disease.