ASXL1, additional sex comb-like 1, is recurrently mutated in a range of myeloid malignancies, including MDS, AML, and chronic myelomonocytic leukemia, and has been noted to be one of the most commonly occurring mutations in patients with clonal hematopoiesis and MDS [7–9]. Here, ASXL1 is linked to myelodysplastic syndrome.