ASXL1 and chronic myelogenous leukemia, BCR-ABL1 positive: We have previously demonstrated through the use of the ASXL1G710X mutant KBM5 CML cell line and the CRISPR/Cas9 homozygous corrected isogenic cells, that in the ASXL1 mutant cells, there was the loss of function of PRC2, resulting in HOXA gene over-expression and resultant myeloid transformation [12].