Notably, adoptive transfer of activin-A-treated CD4+ T cells (act-A-CD4+ T cells) into tumor-bearing CD4−/− mice led to restrained lung tumor formation in comparison to mice transferred with PBS-treated CD4+ T cells (PBS-CD4+ T cells) or mock-transferred CD4−/− mice (no cells) (Fig. 3B-D). This evidence concerns the gene CD4 and neoplasm.