APOC3 and coronary artery disorder: Therefore, the purpose of this study was: 1) to perform gene-centric analysis of the APOC3 region to identify common and rare variants associated with TG; 2) to verify the cardioprotective role of earlier reported LoF/reduced-function variants of the APOC3; and 3) to analyze whether genetically raised TG due to APOC3 variation would increase the development of CAD, in Asian Indian and other multi-ethnic cohorts comprising 396,644 individuals.