Several recent studies have reported the utility of various inflammation-based and/or nutritional markers as predictors of postoperative complications and poor prognosis in esophageal cancer, such as the Onodera’s prognostic nutritional index (PNI), CRP-to-albumin ratio (CAR) and modified Glasgow prognostic score (mGPS), which are calculated based on laboratory data including serum albumin or CRP [6–8]. The gene discussed is CRP; the disease is esophageal cancer.