In 501 patients with mild chronic kidney disease, there were no differences in kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (N-GAL) in patients that had AKI or not after a CT with CM [24] Also in a study of 77 critically ill patients tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7) were not different in patients with or without AKI [25]. Here, IGFBP7 is linked to chronic kidney disease.