An analysis of data from 18 countries from the “Prospective Lynch Syndrome Database (PLSD)”22demonstrated that 95% of centers offer total hysterectomy and bilateral salpingo-oophorectomy (TH + BSO) for patients with deleterious mutations in MLH1 and MSH2, 91% in MSH6 and 67% in PSM2. This evidence concerns the gene MSH2 and Lynch syndrome.