Furthermore, several pathways usually found altered in CRC came up in our analysis such as “PI3K-Akt signalling pathway” (p-value = 1.2x10-21; FDR = 1.9x10-20), “RAS signalling pathway” (p-value = 8.1x10-11; FDR = 4.5x10-10), “TP53 signalling pathway” (p-value = 7.1x10-7; FDR = 2.3x10-6), “TGF-beta signalling pathway” (p-value = 7.6x10-7; FDR = 2.4X10-6), “WNT signalling pathway” (p-value = 8.5x10-8 and FDR = 3.0x10-7 and “MAPK signalling pathway” (p-value = 2.39x10-08; FDR = 2.96x10-05). The gene discussed is PIK3CA; the disease is colorectal carcinoma.