Among the remaining 25 miRNAs, miR-125a-5p a well-known deregulated miRNA in CRC [37] presented the highest number of interactions with CRC associated genes, interacting with a total of 44 genes among which were AKT1, EGFR, TP53, VEGFA, SMAD2 and SMAD4 (Figure 4 and Supplementary Table 2). This evidence concerns the gene SMAD4 and colorectal carcinoma.