Alternative non-invasive tests, such as the faecal occult blood tests (FOBTs) and serum biomarkers as Carcinoembryonic antigen (CEA) and the Carbohydrate antigen 19-9 (CA19-9), have been proposed for CRC but, their lack of specificity and sensitivity has limited their use [3, 6, 8, 13–15]. Here, CEACAM5 is linked to colorectal carcinoma.