In the present study, nine potential colorectal tumor markers (DPEP1, ARID3A, SLC5A6, AXIN2, LY6G6D, NKD1, CEL, LAPTM4B, and GRM8) were screened out from two different independent databases (TCGA database and GEO datasets) by bioinformatics analysis. This evidence concerns the gene NKD1 and colorectal neoplasm.