Given the positive correlation of increased EHMT1 in the human frontal cortex with AD progression (Lu et al., 2004; Sharma et al., 2017; Yuan et al., 2020; Zheng et al., 2019), we examined the level of EHMT1 (GLP) and EHMT2 (G9a) in the PFC of an AD‐associated mouse model, P301S Tau mice (Mathys et al., 2019; Yoshiyama et al., 2007; Zhang et al., 2014). This evidence concerns the gene EHMT1 and Alzheimer disease.