Genetic mutations in ABCA1 (Tangier disease), LCAT (familial lecithin:cholesterol acyltransferase deficiency), ApoA1 (familial apolipoprotein (Apo) A1 deficiency), and UBIAD1 (Schnyder corneal dystrophy, SCD) all result in corneal accumulation of lipids including cholesterol. This evidence concerns the gene ABCA1 and hyperinsulinemic hypoglycemia, familial, 4.