We selected a cut-off unique to our at-risk spine pain cohort to maximize its accuracy for this population, and clinicians using this cut-off should be aware of instances in which the CRP may be lower than our cut-off in PSI patients, especially those with cirrhotic liver disease or concurrent antibiotic use (5 of the 11 misses or near-misses in Figure 4).23–,25 In this study, the presence of other risk variables heightened suspicion of infection, which maintained our high sensitivity for these cases. Here, CRP is linked to infection.