CRP and liver disorder: We selected a cut-off unique to our at-risk spine pain cohort to maximize its accuracy for this population, and clinicians using this cut-off should be aware of instances in which the CRP may be lower than our cut-off in PSI patients, especially those with cirrhotic liver disease or concurrent antibiotic use (5 of the 11 misses or near-misses in Figure 4).23–,25 In this study, the presence of other risk variables heightened suspicion of infection, which maintained our high sensitivity for these cases.