ACTN1 and neoplasm: Similarly, the aberrant expression of ACTN1 has been observed in oral, colon, hepatocellular carcinoma, acute myeloid leukemia, and lung adenocarcinoma, contributing to tumor oncogenesis and metastasis by diverse signaling pathways such as Hippo signaling and FAK/Src/JAK2/STAT3 signaling [16–23].