When GSK3β is inhibited by AKT, free β-catenin accumulate and translocate to the nucleus, ultimately activating downstream target genes such as cyclin D1, C-Myc, CD44, FN1, C-JUN, Slug, L1CAM, and MMP14; thus contributing to tumorigenesis and EMT of cancer [37]. The gene discussed is CD44; the disease is cancer.