As the PGC1 family of transcriptional coactivators such as PGC1α and PGC1β, are master regulators modulating mitochondrial transcription factor A (TFAM) to maintain mitochondrial function and mtDNA levels, we detected PGC1α and PGC1β protein levels in NSCLC spheres and cells. This evidence concerns the gene TFAM and non-small cell lung carcinoma.