Morales-Sosa M et al. observed the neuroprotective effect of celecoxib in neonatal SD rats and found that celecoxib can block proinflammatory proteins to reduce epilepsy susceptibility via the key HMGB1/TLR4 pathway, which is implicated participated in the evolution of diseases with inflammatory processes [36]. The gene discussed is TLR4; the disease is epilepsy.