CASP8 and non-small cell lung carcinoma: In the presence of ANTP-SMACN7, the expressions of caspase-3 and caspase-9 and their cleaved forms were further enhanced by high LET IR with carbon and Fe particles in both NSCLC cells, whereas the effect on caspase-8 was undetectable in A549 and NCI-H460 cells (Figure 3B).