Since mice lacking Nhe3 display a susceptibility to DSS-induced colitis (Kiela et al., 2009), electrolyte flux and imbalance in the intestine, coupled with alterations in the microbiome, may be the distal drivers of increased susceptibility to chemical-induced colitis (Prasad and Visweswariah, 2021). The gene discussed is SLC9A3; the disease is colitis.