In particular, no behavioral studies have been conducted in mice featuring a mutation in the ‘hotspot’ central region of the Dmd gene, which is frequently mutated in DMD patients (63%) and leads to a cumulative loss of Dp427 and Dp140, despite its association with more severe cognitive impairments (Ricotti et al., 2016; Felisari et al., 2000; Beroud et al., 2007; Daoud et al., 2009a; Taylor et al., 2010; Lorusso et al., 2013; Colombo et al., 2017). The gene discussed is DMD; the disease is Duchenne muscular dystrophy.