Dystroglycan has been implicated in basement membrane formation, cell migration and corticogenesis (Paprocka et al., 2021), as defective glycosylation of the extracellular component of the dystroglycan subcomplex results in defects of the glia limitans and cortical plate disorganization, with overmigration of neurons into the arachnoid space in the Walker–Warburg, Fukuyama congenital muscular dystrophy and muscle-eye-brain syndromes associated with intellectual disability (Godfrey et al., 2007; Guimaraes and Dahmoush, 2020). The gene discussed is DAG1; the disease is muscle-eye-brain disease.