Furthermore, mice with nephric duct-specific deletion of Yap1 exhibited defects in ureter-bladder junction (Reginensi et al., 2015), and renal tubule-specific Mst1/2 deletion induced hyperproliferation of renal tubular epithelial cells and renal fibrosis (Xu et al., 2020). This evidence concerns the gene YAP1 and renal fibrosis.