PRPF8 and type 2 diabetes mellitus: SC preadipocytes from IR/T2D obese individuals exhibited lower expression levels of splicing-related genes than NG obese subjects, including components of major spliceosome (PRPF8, RNU5, SF3B1 tv1, TCERG1, and U2AF1), and splicing factors (CELF1, MAGOH, RBM3, RBM45, SFPQ, and SNW1) (Figure 2A and B, and Figure 2—figure supplement 1).