Analysis of markers of LD biogenesis and growth (BSCL-2, CIDEB, CIDEC), showed similar trends to those observed for PPARG and SREBF1 upon manipulation of PRPF8 expression in SC preadipocytes from either NG or IR/T2D obese individuals (Figure 4E–G). Here, SREBF1 is linked to type 2 diabetes mellitus.