RNU12 and obesity due to melanocortin 4 receptor deficiency: Notably, and similar to that observed for morbidly obese individuals from cohort 1 (Figure 2A and Figure 2—figure supplements 1 and 2), a significant decrease in the expression levels of all the genes tested, except RNU12, was observed in T2D vs. NG individuals with simple obesity (Figure 2C and Figure 2—figure supplement 3).