Notwithstanding this, the observation that PRP8 re-expression in PRPF8-silenced SGBS cells and, most notably, in SC preadipocytes from IR/T2D obese individuals, can restore the expression and/or isoform balance of genes such as PPARG, BSCL2, CIDEB, or CIDEC, as well as normal LD content, supports a prominent role for this protein in lipid accumulation in adipocytes. This evidence concerns the gene CIDEB and type 2 diabetes mellitus.