RAD23A and obesity due to melanocortin 4 receptor deficiency: Nevertheless, the expression of some of these ERAD-related genes, such as RAD23A, which was higher in SC preadipocytes from NG individuals with simple obesity as compared to lean individuals, decreased in the transition from NG to T2D in obesity (Figure 6—figure supplement 2D), an effect that was also observed in morbid obesity (Figure 6D).