Notably, and similar to that observed for morbidly obese individuals from cohort 1 (Figure 2A and Figure 2—figure supplements 1 and 2), a significant decrease in the expression levels of all the genes tested, except RNU12, was observed in T2D vs. NG individuals with simple obesity (Figure 2C and Figure 2—figure supplement 3). This evidence concerns the gene RNU1-2 and obesity due to melanocortin 4 receptor deficiency.