PLEK and multiple endocrine neoplasia type 2: Crowder et al. showed that DOK6 is localized in the plasma membrane through its pleckstrin homology (PH) domain and is phosphorylated upon the activation of RET by the mutation of multiple endocrine neoplasia type 2A (MEN2A) or the stimulation of GDNF, and DOK6 is a substrate of the RET signalling pathway.11, 25, 30, 31